Tay-Sachs disease is a devastating and rare genetic disorder of the central nervous system (CNS). Caused by a deficiency of the enzyme hexosaminidase A (Hex-A), it leads to the accumulation of GM2 ganglioside in neurons, resulting in progressive neurological damage. Affecting approximately 1 in every 320,000 births in the United States, Tay-Sachs disease has become a critical focus in the field...