Once you reach the endgame in Diablo 4, regular buy diablo 4 items bosses are no longer enough. To get the best legendary and unique loot, you’ll need to take on Uber Bosses—powerful enemies with enhanced difficulty and exclusive rewards. These bosses drop some of the rarest loot in the game, including class-specific uniques and high-tier crafting materials.

This guide will break down the loot tables for Diablo 4’s Uber Bosses, helping you find the best rewards for your build.

1. Duriel, King of Maggots – Poison & Shadow Master

  • Location: Found in Endgame Helltide Events
  • Summoning Requirements: Use Scorched Grubs from Nightmare Dungeons

Duriel’s Loot Table

Duriel is known for poison-based attacks and has some of the best poison-themed uniques in the game.

  • Unique & Legendary Gear

    • Venomous Crown (Unique Helm) – Increases poison resistance and boosts poison damage.
    • Serpent’s Coil (Unique Ring) – Grants life-leech when poisoning enemies.
    • Plaguebringer’s Fang (Unique Dagger) – Critical hits apply a powerful poison effect.

  • Crafting Materials

    • Demonic Essence (used for high-tier poison crafting)
    • Forgotten Souls (rare currency for upgrading legendary items)

2. Andariel, Maiden of Anguish – Fire & Shadow Nightmare

  • Location: Tormented Strongholds (World Tier 4)
  • Summoning Requirements: Collect Tainted Blood Crystals

Andariel’s Loot Table

Andariel’s loot pool includes fire and shadow-based gear, perfect for damage-over-time builds.

  • Unique & Legendary Gear

    • Anguish’s Embrace (Unique Chest Armor) – Increases damage when taking fire or shadow damage.
    • Cursed Thorn (Unique Dagger) – Adds burning and bleeding effects to critical strikes.
    • Maiden’s Amulet – Reduces damage from burning enemies and enhances fire resistance.

  • Crafting Materials

    • Flame-Forged Shards (used in high-level fire upgrades)
    • Scattered Prisms

3. Lilith, Daughter of Hatred – The Ultimate Challenge

  • Location: Final Story Encounter & Uber Lilith in World Tier 4
  • Summoning Requirements: Must complete the Cathedral of Hatred questline

Lilith’s Loot Table

Lilith is one of the hardest bosses in Diablo 4, dropping some of the strongest endgame gear.

  • Unique & Legendary Gear

    • Hatred’s Embrace (Unique Chest Armor) – Grants increased damage at low health.
    • Lilith’s Whisper (Unique Amulet) – Enhances all shadow and necrotic abilities.
    • Demon’s Pact (Unique Ring) – Increases damage resistance when below 25% health.

  • Crafting Materials

    • Hellforged Ashes (used in final-tier item enhancements)
    • Forgotten Souls

4. Varshan, the Consumed – Enhanced Uber Version

  • Location: Torment Nightmare Dungeons
  • Summoning Requirements: Use Corrupted Essence

Varshan’s Loot Table

This boss is an upgraded version of the dungeon boss, featuring deadlier attacks and better loot.

  • Unique & Legendary Gear

    • Putrid Mask (Unique Helm) – Boosts disease damage and increases healing when attacking diseased enemies.
    • Rotting Gauntlets – Grants increased poison and shadow resistance.
    • Death’s Grip (Unique Belt) – Reduces cooldowns on damage-over-time effects.

  • Crafting Materials

    • Putrid Essence (used for upgrading poison and disease-based items)
    • Forgotten Souls

5. The Echo of Mephisto – Nightmare Reaper

  • Location: Hellborn Citadel
  • Summoning Requirements: Use Soul Fragments from Helltide events

Mephisto’s Loot Table

Mephisto is an Uber-tier nightmare boss dropping some of the most powerful necrotic and shadow-based loot.

  • Unique & Legendary Gear

    • Soulrender (Unique Sword) – Boosts shadow damage and grants lifesteal on kills.
    • Mephisto’s Cloak (Unique Chest) – Reduces shadow cooldowns and increases dark resistance.
    • Demonic Pact (Unique Amulet) – Enhances all necrotic and fear effects.

  • Crafting Materials

    • Darkened Bone Shards
    • Scattered Prisms

Best Uber Bosses to Farm for High-End Loot

  • For Poison Builds: Duriel
  • For Fire Builds: Andariel
  • For Shadow Builds: Mephisto
  • For Survivability & Tank Builds: Lilith
  • For Damage-over-Time Builds: Varshan

Final Thoughts

Uber bosses in Diablo 4’s endgame are the best sources for rare uniques, powerful legendaries, and crafting materials. If you’re serious about min-maxing your build, farming these bosses will be essential.

Stay tuned for the next blog, where we’ll cover D4 Materials for Sale Seasonal & Event Boss Loot Tables!